Syk and Zap-70 function redundantly to promote angioblast migration
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منابع مشابه
Distinct roles for Syk and ZAP-70 during early thymocyte development
The spleen tyrosine kinase (Syk) and zeta-associated protein of 70 kD (ZAP-70) tyrosine kinases are both expressed during early thymocyte development, but their unique thymic functions have remained obscure. No specific role for Syk during beta-selection has been established, and no role has been described for ZAP-70 before positive selection. We show that Syk and ZAP-70 provide thymocytes with...
متن کاملDifferential Activation of the Tyrosine Kinases ZAP-70 and Syk After FcgRI Stimulation
Engagement of the high-affinity IgG Fc receptor (FcgRI) actiSyk nor MAP kinase activation was affected by the presence of ZAP-70. Although transduced ZAP-70 had in vitro kinase vates a signal transduction pathway involving tyrosine phosphorylation of associated kinases. We compared the activity and associated with FceRIg after receptor aggregation, it was not tyrosine phosphorylated. In contras...
متن کاملDifferential intrinsic enzymatic activity of Syk and Zap-70 protein-tyrosine kinases.
Syk and Zap-70 are related protein-tyrosine kinases implicated in antigen and Fc receptor signaling. While Zap-70 is restricted to T-cells and natural killer cells, Syk accumulates in B-cells, mast cells, platelets, and immature T-cells. In addition, we found that an isoform of Syk (SykB), which carries a 23-amino acid deletion in the "linker" region, is prominently expressed in bone marrow. To...
متن کاملSyk and ZAP-70 Mediate Recruitment of p56~/CD4 to the Activated T Cell Receptor/CD3/~" Complex
During antigen recognition by T cells, CD4 and the T-cell receptor (TCR)/CD3/~" complex are thought to interact with the same major histocompatibility complex II molecule in a stable ternary complex. Evidence has suggested that the association of CD4 with TCR/CD3/~" requires the interaction of the protein tyrosine kinase p56 ~k with CD4. We have taken a biochemical approach to understand the me...
متن کاملSyk and ZAP-70 mediate recruitment of p56lck/CD4 to the activated T cell receptor/CD3/zeta complex
During antigen recognition by T cells, CD4 and the T-cell receptor (TCR)/CD3/zeta complex are thought to interact with the same major histocompatibility complex II molecule in a stable ternary complex. Evidence has suggested that the association of CD4 with TCR/CD3/zeta requires the interaction of the protein tyrosine kinase p56lck with CD4. We have taken a biochemical approach to understand th...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2010
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2010.01.011